The IIPImage server now has support for the Zoomify client in SVN. It works with both the official flash client and the Zoomify patched OpenLayers javascript client. Work carried out thanks to an R&D grant for the Old Maps Online project from the Ministry of Culture of the Czech Republic. The server path for the client should simply be set to /fcgi-bin/iipsrv.fcgi?Zoomify=/path.tif.
See this post for further details and a Zoomify demo running off an iipsrv back-end.